Antihyperglycemic Activity Antioxidant Enzymes and Histopathological Studies of Salacia oblonga in Streptozotocin Nicotinamide Induced Type 2 Diabetic Rats
نویسندگان
چکیده
Salacia oblonga (Celastraceae), a traditional ayurvedic herbal plant commonly called as ponkoranti. The antidiabetic and Histopathological studies of aqueous stem extracts carried in Streptozotocin-nicotinamide induced diabetic rats which were orally treated with glibenclamide at lower (250 mg/kg) higher (500 concentrations. normal administrated for the oral glucose tolerance test 0, 30, 60 120 min after load. Fasting blood levels measured by oxidase strips glucometer. protective effect was evaluated studying antioxidant enzymes, lipid peroxidation changes treatment period. Treatment done 500 mg/kg extract produced more improved protein (1.18±1.45 mg), superoxide dismutase (229.15±1.52 U/mg protein), Catalase (19.51±1.35 U/min/mg Glutathione (1.54±.29 peroxidase (1.74±1.56 U/min/mg) reduced (1.76±2.31 μm/min/mg). From study, it found that potentially increase antioxidants peroxidation. significantly level (p<0.001). alterations restored significant on vital organs such liver pancreas demonstrates usage potential endangered plant. spectral analysis (gas chromatography-mass spectrometry) explored natural chemical constituents responsible activity. Further preclinical clinical trials are required to confirm extract.
منابع مشابه
Hypoglycaemic and anti-oxidant activity of Salacia oblonga Wall. extract in streptozotocin-induced diabetic rats.
The petroleum ether extract of the root bark of S. oblonga Wall. (Celastraceae) (SOB) was studied in streptozotocin (STZ) diabetic rats and anti-lipid peroxidative activity of the same was studied in the cardiac tissue. SOB prevented significantly the streptozotocin-induced hyperglycaemia and hypoinsulinaemia. It also produced a significant decrease in peroxidation products viz. thiobarbituric ...
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ژورنال
عنوان ژورنال: Indian Journal of Pharmaceutical Sciences
سال: 2022
ISSN: ['0250-474X', '1998-3743']
DOI: https://doi.org/10.36468/pharmaceutical-sciences.1103